6G3Q

Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine

6G3Q の概要

• エントリーDOI: 10.2210/pdb6g3q/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, famotidine, ... (5 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29786.03

構造登録者

Ferraroni, M.,Supuran, C.T.,Angeli, A. (登録日: 2018-03-26, 公開日: 2018-11-28, 最終更新日: 2025-10-01)

主引用文献

Angeli, A.,Ferraroni, M.,Supuran, C.T.
Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases.
ACS Med Chem Lett, 9:1035-1038, 2018

PubMed Abstract: Famotidine, an antiulcer drug incorporating a sulfamide motif, was investigated as carbonic anhydrase inhibitor (CAI). It acts as a nanomolar inhibitor of several human (hCA II, VI, VII and XII) and CAs. The high resolution X-ray structures of famotidine bound to hCA I and II revealed interesting aspects related to its CA inhibition mechanism, offering the possibility to develop antibacterials with a novel mechanism of action.

PubMed: 30344913
DOI: 10.1021/acsmedchemlett.8b00334

実験手法

X-RAY DIFFRACTION (1.01 Å)