6G38

Crystal structure of haspin in complex with tubercidin

6G38 の概要

• エントリーDOI: 10.2210/pdb6g38/pdb
• 関連するPDBエントリー: 6g34
• 分子名称: Serine/threonine-protein kinase haspin, '2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: kinase, inhibitors, slow off-rate, kinetics, halogen, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41389.15

構造登録者

Heroven, C.,Chaikuad, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2018-03-24, 公開日: 2018-04-18, 最終更新日: 2024-01-17)

• 主引用文献: Heroven, C.,Georgi, V.,Ganotra, G.K.,Brennan, P.,Wolfreys, F.,Wade, R.C.,Fernandez-Montalvan, A.E.,Chaikuad, A.,Knapp, S.; Halogen-Aromatic pi Interactions Modulate Inhibitor Residence Times.; Angew. Chem. Int. Ed. Engl., 57:7220-7224, 2018; PubMed: 29601130; DOI: 10.1002/anie.201801666

実験手法

X-RAY DIFFRACTION (1.47 Å)