6G31

Crystal structure of human geranylgeranyl diphosphate synthase mutant D188Y bound to zoledronate

6G31 の概要

• エントリーDOI: 10.2210/pdb6g31/pdb
• 分子名称: Geranylgeranyl pyrophosphate synthase, ZOLEDRONIC ACID, MAGNESIUM ION (3 entities in total)
• 機能のキーワード: geranylgeranyl diphosphate synthase, mevalonate pathway, prenyltransferase, ggpps, bisphosphonates, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 429952.46

構造登録者

Lisnyansky, M.,Kapelushnik, N.,Ben-Bassat, A.,Marom, M.,Loewenstein, A.,Khananshvili, D.,Giladi, M.,Haitin, Y. (登録日: 2018-03-24, 公開日: 2018-10-17, 最終更新日: 2024-01-17)

• 主引用文献: Lisnyansky, M.,Kapelushnik, N.,Ben-Bassat, A.,Marom, M.,Loewenstein, A.,Khananshvili, D.,Giladi, M.,Haitin, Y.; Reduced Activity of Geranylgeranyl Diphosphate Synthase Mutant Is Involved in Bisphosphonate-Induced Atypical Fractures.; Mol. Pharmacol., 94:1391-1400, 2018; PubMed: 30275041; DOI: 10.1124/mol.118.113670

実験手法

X-RAY DIFFRACTION (3 Å)