6G2Q

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHCL (S-isomer), beta, gamma dTTP analogue

6G2Q の概要

• エントリーDOI: 10.2210/pdb6g2q/pdb
• 分子名称: Template Strand, Primer Strand, Downstream Primer Strand, ... (9 entities in total)
• 機能のキーワード: dna polymerase beta, conformational change, enzyme mechanism, lfer, replication
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48319.24

構造登録者

Batra, V.K.,Wilson, S.H. (登録日: 2018-03-23, 公開日: 2018-07-04, 最終更新日: 2024-01-17)

• 主引用文献: Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.; Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.; Biochemistry, 57:3934-3944, 2018; PubMed: 29874056; DOI: 10.1021/acs.biochem.8b00418

実験手法

X-RAY DIFFRACTION (2.148 Å)