PPAR gamma mutant complex

Summary for 6FZG

DescriptorPeroxisome proliferator-activated receptor gamma, (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight32129.78
Rochel, N. (deposition date: 2018-03-14, release date: 2019-02-13)
Primary citation
Rochel, N.,Krucker, C.,Coutos-Thevenot, L.,Osz, J.,Zhang, R.,Guyon, E.,Zita, W.,Vanthong, S.,Hernandez, O.A.,Bourguet, M.,Badawy, K.A.,Dufour, F.,Peluso-Iltis, C.,Heckler-Beji, S.,Dejaegere, A.,Kamoun, A.,de Reynies, A.,Neuzillet, Y.,Rebouissou, S.,Beraud, C.,Lang, H.,Massfelder, T.,Allory, Y.,Cianferani, S.,Stote, R.H.,Radvanyi, F.,Bernard-Pierrot, I.
Recurrent activating mutations of PPAR gamma associated with luminal bladder tumors.
Nat Commun, 10:253-253, 2019
PubMed: 30651555 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-08157-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20930 1.2% 1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report