6FYR

X-RAY STRUCTURE OF CLK3-KD(GP-[275-632], NON-PHOS.)/Cpd-2 AT 1.42A

6FYR の概要

• エントリーDOI: 10.2210/pdb6fyr/pdb
• 関連するPDBエントリー: 6FYI 6FYK 6FYL 6FYO 6FYP
• 分子名称: Dual specificity protein kinase CLK3, 6-~{tert}-butyl-~{N}-[6-(1~{H}-pyrazol-4-yl)-1~{H}-imidazo[1,2-a]pyridin-2-yl]pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: splicing, transferase, kinase, tyrosine-protein kinase, serine/ threonine- protein kinase, nucleotide-binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42615.72

構造登録者

Kallen, J. (登録日: 2018-03-12, 公開日: 2018-07-18, 最終更新日: 2024-01-17)

• 主引用文献: Kallen, J.,Bergsdorf, C.,Arnaud, B.,Bernhard, M.,Brichet, M.,Cobos-Correa, A.,Elhajouji, A.,Freuler, F.,Galimberti, I.,Guibourdenche, C.,Haenni, S.,Holzinger, S.,Hunziker, J.,Izaac, A.,Kaufmann, M.,Leder, L.,Martus, H.J.,von Matt, P.,Polyakov, V.,Roethlisberger, P.,Roma, G.,Stiefl, N.,Uteng, M.,Lerchner, A.; X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.; ChemMedChem, 13:1997-2007, 2018; PubMed: 29985556; DOI: 10.1002/cmdc.201800344

実験手法

X-RAY DIFFRACTION (1.42 Å)