6FVZ
Crystal structure of human monoamine oxidase B (MAO B) in complex with dimethylphenyl-chromone-carboxamide
Summary for 6FVZ
Entry DOI | 10.2210/pdb6fvz/pdb |
Descriptor | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ~{N}-(3,4-dimethylphenyl)-4-oxidanylidene-chromene-3-carboxamide, ... (6 entities in total) |
Functional Keywords | parkinson's disease, drug design, chromone, inhibitor, flavoprotein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 120690.49 |
Authors | Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. (deposition date: 2018-03-05, release date: 2018-04-25, Last modification date: 2024-01-17) |
Primary citation | Reis, J.,Manzella, N.,Cagide, F.,Mialet-Perez, J.,Uriarte, E.,Parini, A.,Borges, F.,Binda, C. Tight-Binding Inhibition of Human Monoamine Oxidase B by Chromone Analogs: A Kinetic, Crystallographic, and Biological Analysis. J. Med. Chem., 61:4203-4212, 2018 Cited by PubMed: 29648817DOI: 10.1021/acs.jmedchem.8b00357 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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