6FVF

The Structure of CK2alpha with CCh503 bound

6FVF の概要

• エントリーDOI: 10.2210/pdb6fvf/pdb
• 分子名称: Casein kinase II subunit alpha, [1-[2-(phenylsulfonylamino)ethyl]piperidin-4-yl]methyl 5-fluoranyl-2-methoxy-1~{H}-indole-3-carboxylate, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: ck2alpha, ck2a, fragment based drug discovery, high concentration screening, selective atp competitive inhibitors, surface entrophy reduction, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40028.13

構造登録者

Brear, P.,Prudent, R.,Laudet, B.,Filhol, O.,Cochet, C.,Sautel, C.,Moucadel, V.,Bestgen, B.,Engel, M.,Ettaoussi, M.,Lomberget, T.,Le Borgne, M.,Kufareva, I.,Abagyan, R.,Hyvonen, M. (登録日: 2018-03-02, 公開日: 2019-06-19, 最終更新日: 2024-01-17)

• 主引用文献: Kufareva, I.,Bestgen, B.,Brear, P.,Prudent, R.,Laudet, B.,Moucadel, V.,Ettaoussi, M.,Sautel, C.F.,Krimm, I.,Engel, M.,Filhol, O.,Borgne, M.L.,Lomberget, T.,Cochet, C.,Abagyan, R.; Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.; Sci Rep, 9:15893-15893, 2019; PubMed: 31685885; DOI: 10.1038/s41598-019-52141-5

実験手法

X-RAY DIFFRACTION (1.47 Å)