6FUH
Complement factor D in complex with the inhibitor (4-((3-(aminomethyl)phenyl)amino)quinazolin-2-yl)-L-valine
Summary for 6FUH
Entry DOI | 10.2210/pdb6fuh/pdb |
Related | 6FUG |
Descriptor | Complement factor D, (2~{S})-2-[[4-[[3-(aminomethyl)phenyl]amino]quinazolin-2-yl]amino]-3-methyl-butanoic acid (3 entities in total) |
Functional Keywords | serine protease, inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 25104.55 |
Authors | Mac Sweeney, A.,Ostermann, N.,Vulpetti, A.,Maibaum, J.,Erbel, P.,Lorthiois, E.,Yoon, T.,Randl, S.,Ruedisser, S. (deposition date: 2018-02-27, release date: 2018-06-06) |
Primary citation | Vulpetti, A.,Ostermann, N.,Randl, S.,Yoon, T.,Mac Sweeney, A.,Cumin, F.,Lorthiois, E.,Rudisser, S.,Erbel, P.,Maibaum, J. Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett, 9:490-495, 2018 Cited by PubMed: 29795765DOI: 10.1021/acsmedchemlett.8b00104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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