6FTW

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-048

Summary for 6FTW

Entry DOI	10.2210/pdb6ftw/pdb
Related	6FTM
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	phosphodiesterase, hydrolase, camp hydrolysis, alternative splicing
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	172643.76
Authors	Singh, A.K.,Brown, D.G. (deposition date: 2018-02-24, release date: 2019-03-20, Last modification date: 2024-01-17)
Primary citation	de Heuvel, E.,Singh, A.K.,Edink, E.,van der Meer, T.,van der Woude, M.,Sadek, P.,Krell-Jorgensen, M.P.,van den Bergh, T.,Veerman, J.,Caljon, G.,Kalejaiye, T.D.,Wijtmans, M.,Maes, L.,de Koning, H.P.,Jan Sterk, G.,Siderius, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors. Bioorg.Med.Chem., 27:3998-4012, 2019 Cited by PubMed: 31327675 DOI: 10.1016/j.bmc.2019.06.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation