6FQU
Crystal structure of CREBBP bromodomain complexd with DR09
Summary for 6FQU
Entry DOI | 10.2210/pdb6fqu/pdb |
Descriptor | CREB-binding protein, 1-[3-[3-[3,3-bis(fluoranyl)piperidin-1-yl]phenyl]-4-ethoxy-phenyl]ethanone (3 entities in total) |
Functional Keywords | inhibitor, bromodomain, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14582.76 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2018-02-14, release date: 2018-08-29, Last modification date: 2024-01-17) |
Primary citation | Zhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules. ACS Med Chem Lett, 9:929-934, 2018 Cited by PubMed: 30258543DOI: 10.1021/acsmedchemlett.8b00286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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