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6FNI

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with NVP-BHG712

Summary for 6FNI
Entry DOI10.2210/pdb6fni/pdb
DescriptorEphrin type-B receptor 4, 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
Functional Keywordsinhibitor, complex, protein tyrosine kinase, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight33991.84
Authors
Kudlinzki, D.,Troester, A.,Witt, K.,Linhard, V.L.,Saxena, K.,Schwalbe, H. (deposition date: 2018-02-04, release date: 2018-08-08, Last modification date: 2024-01-17)
Primary citationTroster, A.,Heinzlmeir, S.,Berger, B.T.,Gande, S.L.,Saxena, K.,Sreeramulu, S.,Linhard, V.,Nasiri, A.H.,Bolte, M.,Muller, S.,Kuster, B.,Medard, G.,Kudlinzki, D.,Schwalbe, H.
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
ChemMedChem, 13:1629-1633, 2018
Cited by
PubMed: 29928781
DOI: 10.1002/cmdc.201800398
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.468 Å)
Structure validation

221051

건을2024-06-12부터공개중

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