6FMO

Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi

6FMO の概要

• エントリーDOI: 10.2210/pdb6fmo/pdb
• 分子名称: Sterol 14alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE, Obtusifoliol, ... (4 entities in total)
• 機能のキーワード: sterol biosynthesis, cyp51, oxidoreductase, monooxygenase, substrate binding, protein binding
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 225050.85

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (登録日: 2018-02-01, 公開日: 2018-10-24, 最終更新日: 2024-01-17)

• 主引用文献: Hargrove, T.Y.,Wawrzak, Z.,Fisher, P.M.,Child, S.A.,Nes, W.D.,Guengerich, F.P.,Waterman, M.R.,Lepesheva, G.I.; Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51.; J. Biol. Chem., 293:19344-19353, 2018; PubMed: 30327430; DOI: 10.1074/jbc.RA118.005850

実験手法