6FHI

Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.

6FHI の概要

• エントリーDOI: 10.2210/pdb6fhi/pdb
• 関連するPDBエントリー: 6FHH
• 分子名称: Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (8 entities in total)
• 機能のキーワード: influenza virus, rna-dependent rna polymerase, viral protein, modified pol ii ctd peptide
• 由来する生物種: Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 278802.00

構造登録者

Lukarska, M.,Cusack, S. (登録日: 2018-01-14, 公開日: 2019-01-30, 最終更新日: 2024-11-13)

• 主引用文献: Claron, M.,Lukarska, M.,Uhrig, U.,Sehr, P.,Drncova, P.,Lewis, J.D.,Will, D.W.,Cusack, S.; Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain; To Be Published,

実験手法

X-RAY DIFFRACTION (2.8 Å)