6FH5

PI3Kg IN COMPLEX WITH Compound 7

6FH5 の概要

• エントリーDOI: 10.2210/pdb6fh5/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 3-methyl-1-(oxan-4-yl)-8-pyridin-3-yl-imidazo[4,5-c]quinolin-2-one (3 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111087.51

構造登録者

Petersen, J.,Barlaam, B. (登録日: 2018-01-12, 公開日: 2019-01-30, 最終更新日: 2024-05-01)

• 主引用文献: Barlaam, B.,Cadogan, E.,Cambell, A.,Colclough, N.,Dishington, A.,Durant, S.,Goldberg, K.,Hassall, L.A.,Hughes, G.D.,MacFaul, P.A.,McGuire, T.M.,Pass, M.,Patel, A.,Pearson, S.,Petersen, J.,Pike, K.G.,Robb, G.,Stratton, N.,Xin, N.,Zhai, B.; Discovery and Optimisation of a Novel Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent and Selective Ataxia Telangiectasia Mutated (ATM) inhibitors; To Be Published,

実験手法

X-RAY DIFFRACTION (2.84 Å)