6FGQ

Ligand complex of RORg LBD

6FGQ の概要

• エントリーDOI: 10.2210/pdb6fgq/pdb
• 分子名称: Nuclear receptor ROR-gamma, methyl 4-[[3-[5-[2-(4-ethylsulfonylphenyl)ethanoylamino]thiophen-3-yl]pyridin-2-yl]oxymethyl]benzoate (3 entities in total)
• 機能のキーワード: rar-related orphan receptor-g (rorg), transcription, rorg ligand, structure-based design
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62938.27

構造登録者

Xue, Y.,Aagaard, A.,Narjes, F. (登録日: 2018-01-11, 公開日: 2018-08-22, 最終更新日: 2024-05-08)

• 主引用文献: Narjes, F.,Xue, Y.,von Berg, S.,Malmberg, J.,Llinas, A.,Olsson, R.I.,Jirholt, J.,Grindebacke, H.,Leffler, A.,Hossain, N.,Lepisto, M.,Thunberg, L.,Leek, H.,Aagaard, A.,McPheat, J.,Hansson, E.L.,Back, E.,Tangefjord, S.,Chen, R.,Xiong, Y.,Hongbin, G.,Hansson, T.G.; Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.; J. Med. Chem., 61:7796-7813, 2018; PubMed: 30095900; DOI: 10.1021/acs.jmedchem.8b00783

実験手法

X-RAY DIFFRACTION (2.37 Å)