6FGL

Crystal Structure of BAZ2A bromodomain in complex with acetylindole compound UZH47

Summary for 6FGL

• Entry DOI: 10.2210/pdb6fgl/pdb
• Related: 5E73
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2A, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 12727.58

Authors

Dalle Vedove, A.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A. (deposition date: 2018-01-11, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Dalle Vedove, A.,Spiliotopoulos, D.,D'Agostino, V.G.,Marchand, J.R.,Unzue, A.,Nevado, C.,Lolli, G.,Caflisch, A.; Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.; ChemMedChem, 13:1479-1487, 2018; PubMed: 29770599; DOI: 10.1002/cmdc.201800234

Experimental method

X-RAY DIFFRACTION (2.1 Å)