6FFT
Neutron structure of human transthyretin (TTR) S52P mutant in complex with tafamidis at room temperature to 2A resolution (quasi-Laue)
Summary for 6FFT
| Entry DOI | 10.2210/pdb6fft/pdb |
| Related | 5NFE 5NFW |
| Descriptor | Transthyretin, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid (3 entities in total) |
| Functional Keywords | homotetramer, prealbumin, mutant-drug complex, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28709.68 |
| Authors | Yee, A.W.,Moulin, M.,Blakeley, M.P.,Haertlein, M.,Mitchell, E.P.,Forsyth, V.T. (deposition date: 2018-01-09, release date: 2019-01-02, Last modification date: 2019-03-20) |
| Primary citation | Yee, A.W.,Aldeghi, M.,Blakeley, M.P.,Ostermann, A.,Mas, P.J.,Moulin, M.,de Sanctis, D.,Bowler, M.W.,Mueller-Dieckmann, C.,Mitchell, E.P.,Haertlein, M.,de Groot, B.L.,Boeri Erba, E.,Forsyth, V.T. A molecular mechanism for transthyretin amyloidogenesis. Nat Commun, 10:925-925, 2019 Cited by PubMed: 30804345DOI: 10.1038/s41467-019-08609-z PDB entries with the same primary citation |
| Experimental method | NEUTRON DIFFRACTION (2 Å) X-RAY DIFFRACTION (2 Å) |
Structure validation
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