6FFI

Crystal Structure of mGluR5 in complex with MMPEP at 2.2 A

6FFI の概要

• エントリーDOI: 10.2210/pdb6ffi/pdb
• 分子名称: Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: 7tm, receptor, gpcr, membrane-protein, signaling protein, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52255.32

構造登録者

Christopher, J.A.,Orgovan, Z.,Congreve, M.,Dore, A.S.,Errey, J.C.,Marshall, F.H.,Mason, J.S.,Okrasa, K.,Rucktooa, P.,Serrano-Vega, M.J.,Ferenczy, G.G.,Keseru, G.M. (登録日: 2018-01-08, 公開日: 2018-03-07, 最終更新日: 2024-01-17)

• 主引用文献: Christopher, J.A.,Orgovan, Z.,Congreve, M.,Dore, A.S.,Errey, J.C.,Marshall, F.H.,Mason, J.S.,Okrasa, K.,Rucktooa, P.,Serrano-Vega, M.J.,Ferenczy, G.G.,Keseru, G.M.; Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu5) X-ray Structures.; J.Med.Chem., 62:207-222, 2019; PubMed: 29455526; DOI: 10.1021/acs.jmedchem.7b01722

実験手法

X-RAY DIFFRACTION (2.2 Å)