6FFB

17beta-hydroxysteroid dehydrogenase 14 variant S205 - mutant Q148A - in complex with a nonsteroidal inhibitor

6FFB の概要

• エントリーDOI: 10.2210/pdb6ffb/pdb
• 分子名称: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: 17b-hsd14, mutation, inhibition, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29803.53

構造登録者

Bertoletti, N.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. (登録日: 2018-01-05, 公開日: 2019-01-30, 最終更新日: 2024-01-17)

• 主引用文献: Badran, M.J.,Bertoletti, N.,Keils, A.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S.; Mutational and structural studies uncover crucial amino acids determining activity and stability of 17 beta-HSD14.; J.Steroid Biochem.Mol.Biol., 189:135-144, 2019; PubMed: 30836176; DOI: 10.1016/j.jsbmb.2019.02.009

実験手法

X-RAY DIFFRACTION (1.65 Å)