6FF9

Mutant R280K of human P53

Summary for 6FF9

• Entry DOI: 10.2210/pdb6ff9/pdb
• Descriptor: Cellular tumor antigen p53, ZINC ION (3 entities in total)
• Functional Keywords: p53, mutant, dna binding, anticancer therapy, dna binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 4
• Total formula weight: 87236.56

Authors

Trovao, F.G.,Gomes, A.S.,Pinheiro, B.,Carvalho, A.L.,Romao, M.J. (deposition date: 2018-01-04, release date: 2018-04-25, Last modification date: 2024-01-17)

• Primary citation: Gomes, A.S.,Trovao, F.,Andrade Pinheiro, B.,Freire, F.,Gomes, S.,Oliveira, C.,Domingues, L.,Romao, M.J.,Saraiva, L.,Carvalho, A.L.; The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding.; Int J Mol Sci, 19:-, 2018; PubMed: 29652801; DOI: 10.3390/ijms19041184

Experimental method

X-RAY DIFFRACTION (2 Å)