6FEQ

Structure of inhibitor-bound ABCG2

Summary for 6FEQ

Entry DOI	10.2210/pdb6feq/pdb
EMDB information	3953 4246
Descriptor	ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ... (5 entities in total)
Functional Keywords	multidrug transporter, abcg2, mb136, inhibitor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	240888.34
Authors	Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Altmann, K.H.,Locher, K.P. (deposition date: 2018-01-03, release date: 2018-04-11, Last modification date: 2020-07-29)
Primary citation	Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Stahlberg, H.,Altmann, K.H.,Locher, K.P. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25:333-340, 2018 Cited by PubMed: 29610494 DOI: 10.1038/s41594-018-0049-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.6 Å)

Structure validation