6FCF
CHK1 KINASE IN COMPLEX WITH COMPOUND 44
Summary for 6FCF
Entry DOI | 10.2210/pdb6fcf/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, 4-[[(2~{R},3~{S})-2-methylpiperidin-3-yl]amino]-2-phenyl-thieno[3,2-c]pyridine-7-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, chk1, kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 32367.41 |
Authors | Read, J.A.,Breed, J. (deposition date: 2017-12-20, release date: 2018-01-17, Last modification date: 2018-02-21) |
Primary citation | Yang, B.,Vasbinder, M.M.,Hird, A.W.,Su, Q.,Wang, H.,Yu, Y.,Toader, D.,Lyne, P.D.,Read, J.A.,Breed, J.,Ioannidis, S.,Deng, C.,Grondine, M.,DeGrace, N.,Whitston, D.,Brassil, P.,Janetka, J.W. Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors. J. Med. Chem., 61:1061-1073, 2018 Cited by PubMed: 29301085DOI: 10.1021/acs.jmedchem.7b01490 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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