6FB3

Teneurin 2 Partial Extracellular Domain

6FB3 の概要

• エントリーDOI: 10.2210/pdb6fb3/pdb
• 分子名称: Teneurin-2, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: ttr, fibronectin, fn-plug, nhl, yd-repeat, antibiotic-binding, colicin, nuclease, cell surface receptor, latrophilin, glycoprotein, cell adhesion
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 853679.91

構造登録者

Jackson, V.A.,Carrasquero, M.,Lowe, E.D.,Seiradake, E. (登録日: 2017-12-18, 公開日: 2018-03-28, 最終更新日: 2024-11-06)

主引用文献

Jackson, V.A.,Meijer, D.H.,Carrasquero, M.,van Bezouwen, L.S.,Lowe, E.D.,Kleanthous, C.,Janssen, B.J.C.,Seiradake, E.
Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction.
Nat Commun, 9:1079-1079, 2018

PubMed Abstract: Teneurins are ancient cell-cell adhesion receptors that are vital for brain development and synapse organisation. They originated in early metazoan evolution through a horizontal gene transfer event when a bacterial YD-repeat toxin fused to a eukaryotic receptor. We present X-ray crystallography and cryo-EM structures of two Teneurins, revealing a ~200 kDa extracellular super-fold in which eight sub-domains form an intricate structure centred on a spiralling YD-repeat shell. An alternatively spliced loop, which is implicated in homophilic Teneurin interaction and specificity, is exposed and thus poised for interaction. The N-terminal side of the shell is 'plugged' via a fibronectin-plug domain combination, which defines a new class of YD proteins. Unexpectedly, we find that these proteins are widespread amongst modern bacteria, suggesting early metazoan receptor evolution from a distinct class of proteins, which today includes both bacterial proteins and eukaryotic Teneurins.

PubMed: 29540701
DOI: 10.1038/s41467-018-03460-0

実験手法

X-RAY DIFFRACTION (2.38 Å)