6F88

Crystal structure of cytochrome P450 CYP260A1 (S276N) bound with progesterone

6F88 の概要

• エントリーDOI: 10.2210/pdb6f88/pdb
• 分子名称: Cytochrome P450 CYP260A1, PROTOPORPHYRIN IX CONTAINING FE, PROGESTERONE, ... (4 entities in total)
• 機能のキーワード: bacterial proteins, sorangium cellulosum, cytochrome p-450 enzyme system, cytochrome p450, hydroxylation, heme, oxidation-reduction, progesterone, histidine, biocatalysis, oxidoreductase
• 由来する生物種: Sorangium cellulosum (strain So ce56) (Polyangium cellulosum (strain So ce56))
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90911.74

構造登録者

Jozwik, I.K.,Thunnissen, A.M.W.H. (登録日: 2017-12-12, 公開日: 2018-03-14, 最終更新日: 2024-01-17)

• 主引用文献: Khatri, Y.,Jozwik, I.K.,Ringle, M.,Ionescu, I.A.,Litzenburger, M.,Hutter, M.C.,Thunnissen, A.W.H.,Bernhardt, R.; Structure-Based Engineering of Steroidogenic CYP260A1 for Stereo- and Regioselective Hydroxylation of Progesterone.; ACS Chem. Biol., 13:1021-1028, 2018; PubMed: 29509407; DOI: 10.1021/acschembio.8b00026

実験手法

X-RAY DIFFRACTION (1.75 Å)