6F83

Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor

Summary for 6F83

• Entry DOI: 10.2210/pdb6f83/pdb
• Descriptor: Galectin-1, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside (3 entities in total)
• Functional Keywords: carbohydrate-recognition, beta sandwich, carbohydrate binding protein, sugar binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 31209.55

Authors

Collins, P.M.,Blanchard, H. (deposition date: 2017-12-12, release date: 2019-01-30, Last modification date: 2024-01-17)

• Primary citation: Peterson, A.,Collins, P.M.,Kahl-Knutsson, B.,Zetterberg, F.R.,Blanchard, H.,Leffler, H.,Nilsson, U.J.; Aromatic heterocycle galectin-1 interactions for selective single-digit nM affinity ligands; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)