6F7B

Crystal structure of the human Bub1 kinase domain in complex with BAY 1816032

6F7B の概要

• エントリーDOI: 10.2210/pdb6f7b/pdb
• 分子名称: Mitotic checkpoint serine/threonine-protein kinase BUB1, 2-[3,5-bis(fluoranyl)-4-[[3-[5-methoxy-4-[(3-methoxypyridin-4-yl)amino]pyrimidin-2-yl]indazol-1-yl]methyl]phenoxy]ethanol, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: bub1, kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42042.86

構造登録者

Holton, S.J.,Siemeister, G.,Mengel, A.,Bone, W.,Schroeder, J.,Zitzmann-Kolbe, S.,Briem, H.,Fernandez-Montalvan, A.,Prechtl, S.,Moenning, U.,von Ahsen, O.,Johanssen, J.,Cleve, A.,Puetter, V.,Hitchcock, M.,von Nussbaum, F.,Brands, M.,Mumberg, D.,Ziegelbauer, K. (登録日: 2017-12-08, 公開日: 2018-12-19, 最終更新日: 2021-05-05)

• 主引用文献: Siemeister, G.,Mengel, A.,Fernandez-Montalvan, A.E.,Bone, W.,Schroder, J.,Zitzmann-Kolbe, S.,Briem, H.,Prechtl, S.,Holton, S.J.,Monning, U.,von Ahsen, O.,Johanssen, S.,Cleve, A.,Putter, V.,Hitchcock, M.,von Nussbaum, F.,Brands, M.,Ziegelbauer, K.,Mumberg, D.; Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP InhibitorsIn VitroandIn Vivo.; Clin.Cancer Res., 25:1404-1414, 2019; PubMed: 30429199; DOI: 10.1158/1078-0432.CCR-18-0628

実験手法

X-RAY DIFFRACTION (2 Å)