6F6N

CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH SERTRALINE

Summary for 6F6N

Entry DOI	10.2210/pdb6f6n/pdb
Related	6F5U 6F6I
Descriptor	Envelope glycoprotein,Envelope glycoprotein,GP1, Envelope glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, benztropine, bepridil, paroxetine, sertraline, toremifene, viral protein
Biological source	Zaire ebolavirus (strain Mayinga-76) (ZEBOV) More
Total number of polymer chains	2
Total formula weight	57865.53
Authors	Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. (deposition date: 2017-12-05, release date: 2018-01-03, Last modification date: 2024-01-17)
Primary citation	Ren, J.,Zhao, Y.,Fry, E.E.,Stuart, D.I. Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection. J. Med. Chem., 61:724-733, 2018 Cited by PubMed: 29272110 DOI: 10.1021/acs.jmedchem.7b01249 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation