6F5M

Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor

Summary for 6F5M

• Entry DOI: 10.2210/pdb6f5m/pdb
• Descriptor: Neutrophil elastase, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: human leukocyte elastase, human neutrophil elastase, parabolic inhibition, glycosylation, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 51575.68

Authors

Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Hautmann, S.,Abell, A.,Guetschow, M.,Niefind, K. (deposition date: 2017-12-01, release date: 2018-08-08, Last modification date: 2024-01-17)

• Primary citation: Hochscherf, J.,Pietsch, M.,Tieu, W.,Kuan, K.,Abell, A.D.,Gutschow, M.,Niefind, K.; Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.; Acta Crystallogr F Struct Biol Commun, 74:480-489, 2018; PubMed: 30084397; DOI: 10.1107/S2053230X1800537X

Experimental method

X-RAY DIFFRACTION (2.7 Å)