Structure of quinolinate synthase with inhibitor-derived quinolinate

Summary for 6F4L

DescriptorQuinolinate synthase A, IRON/SULFUR CLUSTER, QUINOLINIC ACID, ... (6 entities in total)
Functional Keywordsnad biosynthesis, iron sulfur cluster, transferase
Biological sourceThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Cellular locationCytoplasm  Q9X1X7
Total number of polymer chains1
Total molecular weight35418.1
Volbeda, A.,Fontecilla-Camps, J.C. (deposition date: 2017-11-29, release date: 2018-04-25, Last modification date: 2018-05-30)
Primary citation
Volbeda, A.,Saez Cabodevilla, J.,Darnault, C.,Gigarel, O.,Han, T.H.,Renoux, O.,Hamelin, O.,Ollagnier-de-Choudens, S.,Amara, P.,Fontecilla-Camps, J.C.
Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
ACS Chem. Biol., 13:1209-1217, 2018
PubMed: 29641168 (PDB entries with the same primary citation)
DOI: 10.1021/acschembio.7b01104
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.221202.2%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6f4l
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Molmil generated image of 6f4l
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Molmil generated image of 6f4l
rotated about y axis by 90°