6F3S

The crystal structure of Glycogen Phosphorylase in complex with 10d

6F3S の概要

• エントリーDOI: 10.2210/pdb6f3s/pdb
• 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, (2~{R},3~{S},4~{R},5~{R},6~{S})-2-(hydroxymethyl)-6-[5-(4-phenylphenyl)-4~{H}-1,2,4-triazol-3-yl]oxane-3,4,5-triol, ... (4 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Oryctolagus cuniculus (Rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98052.94

構造登録者

Kyriakis, E.,Stamati, E.C.V.,Stravodimos, G.A.,Skamnaki, V.T.,Leonidas, D.D. (登録日: 2017-11-28, 公開日: 2018-02-28)

• 主引用文献: Kun, S.,Begum, J.,Kyriakis, E.,Stamati, E.C.V.,Barkas, T.A.,Szennyes, E.,Bokor, E.,Szabo, K.E.,Stravodimos, G.A.,Sipos, A.,Docsa, T.,Gergely, P.,Moffatt, C.,Patraskaki, M.S.,Kokolaki, M.C.,Gkerdi, A.,Skamnaki, V.T.,Leonidas, D.D.,Somsak, L.,Hayes, J.M.; A multidisciplinary study of 3-( beta-d-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: Computation, synthesis, crystallography and kinetics reveal new potent inhibitors.; Eur J Med Chem, 147:266-278, 2018; PubMed: 29453094; DOI: 10.1016/j.ejmech.2018.01.095

実験手法

X-RAY DIFFRACTION (1.9 Å)