6F3I
IRAK4 IN COMPLEX WITH inhibitor
Summary for 6F3I
Entry DOI | 10.2210/pdb6f3i/pdb |
Descriptor | Interleukin-1 receptor-associated kinase 4, (3~{R})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | irak4, kinase, inhibitor, cancer, signaling protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NWZ3 |
Total number of polymer chains | 2 |
Total formula weight | 74007.31 |
Authors | Xue, Y.,Degorce, S.L.,Robb, G.R.,Ferguson, A.D. (deposition date: 2017-11-28, release date: 2018-05-23) |
Primary citation | Degorce, S.L.,Anjum, R.,Dillman, K.S.,Drew, L.,Groombridge, S.D.,Halsall, C.T.,Lenz, E.M.,Lindsay, N.A.,Mayo, M.F.,Pink, J.H.,Robb, G.R.,Scott, J.S.,Stokes, S.,Xue, Y. Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4. Bioorg. Med. Chem., 26:913-924, 2018 Cited by PubMed: 29398441DOI: 10.1016/j.bmc.2018.01.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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