6F3I

IRAK4 IN COMPLEX WITH inhibitor

6F3I の概要

• エントリーDOI: 10.2210/pdb6f3i/pdb
• 分子名称: Interleukin-1 receptor-associated kinase 4, (3~{R})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: irak4, kinase, inhibitor, cancer, signaling protein
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9NWZ3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74007.31

構造登録者

Xue, Y.,Degorce, S.L.,Robb, G.R.,Ferguson, A.D. (登録日: 2017-11-28, 公開日: 2018-05-23)

• 主引用文献: Degorce, S.L.,Anjum, R.,Dillman, K.S.,Drew, L.,Groombridge, S.D.,Halsall, C.T.,Lenz, E.M.,Lindsay, N.A.,Mayo, M.F.,Pink, J.H.,Robb, G.R.,Scott, J.S.,Stokes, S.,Xue, Y.; Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.; Bioorg. Med. Chem., 26:913-924, 2018; PubMed: 29398441; DOI: 10.1016/j.bmc.2018.01.008

実験手法

X-RAY DIFFRACTION (2.14 Å)