6F3B
Crystal structure of human carbonic anhydrase I in complex with the 1-(2-hydroxy-5-sulfamoylphenyl)-3-[(4-methylphenyl)methyl]urea inhibitor
Summary for 6F3B
Entry DOI | 10.2210/pdb6f3b/pdb |
Descriptor | Carbonic anhydrase 1, ZINC ION, 1-[(4-methylphenyl)methyl]-3-(2-oxidanyl-5-sulfamoyl-phenyl)urea, ... (6 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 59008.32 |
Authors | Ferraroni, M.,Supuran, C.T.,Chiapponi, D.,Bozdag, M. (deposition date: 2017-11-28, release date: 2018-10-10, Last modification date: 2024-01-17) |
Primary citation | Bozdag, M.,Carta, F.,Ceruso, M.,Ferraroni, M.,McDonald, P.C.,Dedhar, S.,Supuran, C.T. Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX. J. Med. Chem., 61:6328-6338, 2018 Cited by PubMed: 29962205DOI: 10.1021/acs.jmedchem.8b00770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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