6F3B

Crystal structure of human carbonic anhydrase I in complex with the 1-(2-hydroxy-5-sulfamoylphenyl)-3-[(4-methylphenyl)methyl]urea inhibitor

6F3B の概要

• エントリーDOI: 10.2210/pdb6f3b/pdb
• 分子名称: Carbonic anhydrase 1, ZINC ION, 1-[(4-methylphenyl)methyl]-3-(2-oxidanyl-5-sulfamoyl-phenyl)urea, ... (6 entities in total)
• 機能のキーワード: lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59008.32

構造登録者

Ferraroni, M.,Supuran, C.T.,Chiapponi, D.,Bozdag, M. (登録日: 2017-11-28, 公開日: 2018-10-10, 最終更新日: 2024-01-17)

• 主引用文献: Bozdag, M.,Carta, F.,Ceruso, M.,Ferraroni, M.,McDonald, P.C.,Dedhar, S.,Supuran, C.T.; Discovery of 4-Hydroxy-3-(3-(phenylureido)benzenesulfonamides as SLC-0111 Analogues for the Treatment of Hypoxic Tumors Overexpressing Carbonic Anhydrase IX.; J. Med. Chem., 61:6328-6338, 2018; PubMed: 29962205; DOI: 10.1021/acs.jmedchem.8b00770

実験手法

X-RAY DIFFRACTION (1.4 Å)