6F25
Crystal structure of human acetylcholinesterase in complex with C35.
Summary for 6F25
Entry DOI | 10.2210/pdb6f25/pdb |
Descriptor | Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | acetylcholinesterase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 123416.54 |
Authors | Dias, J.,Nachon, F. (deposition date: 2017-11-23, release date: 2018-12-12, Last modification date: 2024-01-17) |
Primary citation | Zueva, I.,Dias, J.,Lushchekina, S.,Semenov, V.,Mukhamedyarov, M.,Pashirova, T.,Babaev, V.,Nachon, F.,Petrova, N.,Nurullin, L.,Zakharova, L.,Ilyin, V.,Masson, P.,Petrov, K. New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology, 155:131-141, 2019 Cited by PubMed: 31132435DOI: 10.1016/j.neuropharm.2019.05.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05199647812 Å) |
Structure validation
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