6F25

Crystal structure of human acetylcholinesterase in complex with C35.

6F25 の概要

• エントリーDOI: 10.2210/pdb6f25/pdb
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: acetylcholinesterase, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123416.54

構造登録者

Dias, J.,Nachon, F. (登録日: 2017-11-23, 公開日: 2018-12-12, 最終更新日: 2024-01-17)

• 主引用文献: Zueva, I.,Dias, J.,Lushchekina, S.,Semenov, V.,Mukhamedyarov, M.,Pashirova, T.,Babaev, V.,Nachon, F.,Petrova, N.,Nurullin, L.,Zakharova, L.,Ilyin, V.,Masson, P.,Petrov, K.; New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease.; Neuropharmacology, 155:131-141, 2019; PubMed: 31132435; DOI: 10.1016/j.neuropharm.2019.05.025

実験手法

X-RAY DIFFRACTION (3.05199647812 Å)