6F1W

Crystal structure of human Casein Kinase I delta in complex with compound 31a

Summary for 6F1W

• Entry DOI: 10.2210/pdb6f1w/pdb
• Descriptor: Casein kinase I isoform delta, SULFATE ION, (9~{R},10~{R},11~{S})-~{N}-[4-[3-(4-fluorophenyl)-5-propan-2-yl-1,2-oxazol-4-yl]pyridin-2-yl]-4-(4-methoxyphenyl)-10,11-bis(oxidanyl)-1,7-diazatricyclo[7.3.0.0^{3,7}]dodeca-3,5-diene-6-carboxamide, ... (5 entities in total)
• Functional Keywords: kinase, inhibitor, complex, ck1, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 75524.05

Authors

Pichlo, C.,Brunstein, E.,Baumann, U. (deposition date: 2017-11-23, release date: 2019-03-13)

• Primary citation: Luxenburger, A.,Schmidt, D.,Ianes, C.,Pichlo, C.,Kruger, M.,von Drathen, T.,Brunstein, E.,Gainsford, G.J.,Baumann, U.,Knippschild, U.,Peifer, C.; Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.; Molecules, 24:-, 2019; PubMed: 30832206; DOI: 10.3390/molecules24050873

Experimental method

X-RAY DIFFRACTION (1.864 Å)