6F14
Crystal structure of the cAMP-dependent protein kinase A cocrystallized with isoquinoline and PKI (5-24)
Summary for 6F14
Entry DOI | 10.2210/pdb6f14/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ISOQUINOLINE, ... (5 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) More |
Total number of polymer chains | 2 |
Total formula weight | 43312.34 |
Authors | Oebbeke, M.,Wienen-Schmidt, B.,Heine, A.,Klebe, G. (deposition date: 2017-11-21, release date: 2018-12-12) |
Primary citation | Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G. Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.867 Å) |
Structure validation
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