6F14

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with isoquinoline and PKI (5-24)

6F14 の概要

• エントリーDOI: 10.2210/pdb6f14/pdb
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ISOQUINOLINE, ... (5 entities in total)
• 機能のキーワード: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• 由来する生物種: Cricetulus griseus (Chinese hamster); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43312.34

構造登録者

Oebbeke, M.,Wienen-Schmidt, B.,Heine, A.,Klebe, G. (登録日: 2017-11-21, 公開日: 2018-12-12, 最終更新日: 2024-10-16)

• 主引用文献: Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G.; Fragment based drug design - Small chemical changes of fragments effecting big changes in binding; To Be Published,

実験手法

X-RAY DIFFRACTION (1.867 Å)