6F0E

Structure of yeast Sec14p with a picolinamide compound

6F0E の概要

• エントリーDOI: 10.2210/pdb6f0e/pdb
• 分子名称: SEC14 cytosolic factor, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-3-fluoranyl-pyridine-2-carboxamide (3 entities in total)
• 機能のキーワード: sec14p, lipid transfer protein, chemogenomics, target identification, functional variomics, co-crystal, antifungal, benzamide, picolinamide, lipid binding protein
• 由来する生物種: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• 細胞内の位置: Golgi apparatus membrane; Peripheral membrane protein: P24280
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36401.02

構造登録者

Hong, Z.,Johnen, P.,Schaaf, G.,Bono, F. (登録日: 2017-11-20, 公開日: 2018-01-17, 最終更新日: 2024-01-17)

• 主引用文献: Pries, V.,Nocker, C.,Khan, D.,Johnen, P.,Hong, Z.,Tripathi, A.,Keller, A.L.,Fitz, M.,Perruccio, F.,Filipuzzi, I.,Thavam, S.,Aust, T.,Riedl, R.,Ziegler, S.,Bono, F.,Schaaf, G.,Bankaitis, V.A.,Waldmann, H.,Hoepfner, D.; Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.; Cell Chem Biol, 25:279-290.e7, 2018; PubMed: 29307839; DOI: 10.1016/j.chembiol.2017.12.007

実験手法

X-RAY DIFFRACTION (2.6 Å)