6F0B

Cytochrome P450 TxtC employs substrate conformational switching for sequential aliphatic and aromatic thaxtomin hydroxylation

6F0B の概要

• エントリーDOI: 10.2210/pdb6f0b/pdb
• 分子名称: Cytochrome P450 monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, (3~{S},6~{S})-1,4-dimethyl-3-[(4-nitro-1~{H}-indol-3-yl)methyl]-6-(phenylmethyl)piperazine-2,5-dione, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, txtc, thaxtomin hydroxylation, oxidoreductase
• 由来する生物種: Streptomyces acidiscabies 84-104
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44494.30

構造登録者

Fulop, V. (登録日: 2017-11-17, 公開日: 2018-12-12, 最終更新日: 2024-01-17)

• 主引用文献: Alkhalaf, L.M.,Barry, S.M.,Rea, D.,Gallo, A.,Griffiths, D.,Lewandowski, J.R.,Fulop, V.,Challis, G.L.; Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC.; J.Am.Chem.Soc., 141:216-222, 2019; PubMed: 30516965; DOI: 10.1021/jacs.8b08864

実験手法

X-RAY DIFFRACTION (2.8 Å)