6EZH

Torpedo californica AChE in complex with indolic multi-target directed ligand

6EZH の概要

• エントリーDOI: 10.2210/pdb6ezh/pdb
• 関連するPDBエントリー: 1ea5 1eve 2w75 6ezg
• 分子名称: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1-(7-chloranyl-4-methoxy-1~{H}-indol-5-yl)-3-[1-(cyclohexylmethyl)piperidin-4-yl]propan-1-one, ... (4 entities in total)
• 機能のキーワード: acetylcholinesterase, multi-target inhibitor, alzheimer desease, hydrolase
• 由来する生物種: Tetronarce californica (Pacific electric ray)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123191.83

構造登録者

Santoni, G.,Lalut, J.,Karila, D.,Lecoutey, C.,Davis, A.,Nachon, F.,Sillman, I.,Sussman, J.,Weik, M.,Maurice, T.,Dallemagne, P.,Rochais, C. (登録日: 2017-11-15, 公開日: 2018-11-21, 最終更新日: 2024-11-13)

主引用文献

Lalut, J.,Santoni, G.,Karila, D.,Lecoutey, C.,Davis, A.,Nachon, F.,Silman, I.,Sussman, J.,Weik, M.,Maurice, T.,Dallemagne, P.,Rochais, C.
Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
Eur J Med Chem, 162:234-248, 2018

PubMed Abstract: Pleiotropic intervention may be a requirement for effective limitation of the progression of multifactorial diseases such as Alzheimer's Disease. One approach to such intervention is to design a single chemical entity capable of acting on two or more targets of interest, which are accordingly known as Multi-Target Directed Ligands (MTDLs). We recently described donecopride, the first MTDL able to simultaneously inhibit acetylcholinesterase and act as an agonist of the 5-HT receptor, which displays promising activities in vivo. Pharmacomodulation of donecopride allowed us to develop a novel series of indole derivatives possessing interesting in vitro activities toward AChE and the σ receptor. The crystal structures of complexes of the most promising compounds with Torpedo californica AChE were solved in order to further understand their mode of inhibition.

PubMed: 30447434
DOI: 10.1016/j.ejmech.2018.10.064

実験手法

X-RAY DIFFRACTION (2.6 Å)