6EZ6

PI3 kinase delta in complex with Methyl 5-(4-(5-((4-isopropylpiperazin-1-yl)methyl)oxazol-2-yl)-1H-indazol-6-yl)-2-methoxynicotinate

6EZ6 の概要

• エントリーDOI: 10.2210/pdb6ez6/pdb
• 関連するPDBエントリー: 6EYZ
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, methyl 2-methoxy-5-[4-[5-[(4-propan-2-ylpiperazin-1-yl)methyl]-1,3-oxazol-2-yl]-2~{H}-indazol-6-yl]pyridine-3-carboxylate (3 entities in total)
• 機能のキーワード: covalent inhibitor, kinase, drug discovery, complex, transferase
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Cytoplasm : O35904
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 121341.91

構造登録者

Convery, M.A.,Campos, S.,Dalton, S.E. (登録日: 2017-11-14, 公開日: 2017-12-27, 最終更新日: 2024-05-08)

• 主引用文献: Dalton, S.E.,Dittus, L.,Thomas, D.A.,Convery, M.A.,Nunes, J.,Bush, J.T.,Evans, J.P.,Werner, T.,Bantscheff, M.,Murphy, J.A.,Campos, S.; Selectively Targeting the Kinome-Conserved Lysine of PI3K delta as a General Approach to Covalent Kinase Inhibition.; J. Am. Chem. Soc., 140:932-939, 2018; PubMed: 29232121; DOI: 10.1021/jacs.7b08979

実験手法

X-RAY DIFFRACTION (2.04 Å)