6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

Summary for 6EUX

Entry DOI	10.2210/pdb6eux/pdb
Descriptor	Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid (3 entities in total)
Functional Keywords	influenza b polymerase pb2 subunit cap-binding domain cap-binding inhibitor, rna binding protein
Biological source	Influenza B virus (B/Memphis/13/2003)
Cellular location	Host nucleus : Q5V8X3
Total number of polymer chains	1
Total formula weight	33406.44
Authors	Cusack, S.,Gaudon, S. (deposition date: 2017-10-31, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citation	Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S. Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46:956-971, 2018 Cited by PubMed: 29202182 DOI: 10.1093/nar/gkx1210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation