6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor

6EUX の概要

• エントリーDOI: 10.2210/pdb6eux/pdb
• 分子名称: Polymerase basic protein 2, (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid (3 entities in total)
• 機能のキーワード: influenza b polymerase pb2 subunit cap-binding domain cap-binding inhibitor, rna binding protein
• 由来する生物種: Influenza B virus (B/Memphis/13/2003)
• 細胞内の位置: Host nucleus : Q5V8X3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33406.44

構造登録者

Cusack, S.,Gaudon, S. (登録日: 2017-10-31, 公開日: 2017-12-13, 最終更新日: 2024-01-17)

• 主引用文献: Pflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.; Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.; Nucleic Acids Res., 46:956-971, 2018; PubMed: 29202182; DOI: 10.1093/nar/gkx1210

実験手法

X-RAY DIFFRACTION (2.05 Å)