6EUL

Butyrylcolinesterase expressed in CHO cells co-crystallised with a rivastigmine analogue

Summary for 6EUL

DescriptorCholinesterase, N-ACETYL-D-GLUCOSAMINE, [3-[(1~{R})-1-(dimethylamino)ethyl]-4-oxidanyl-phenyl] ~{N}-ethyl-~{N}-methyl-carbamate, ... (5 entities in total)
Functional Keywordsbutyrylcholinesterase, alzheimer disease, organophosphate, carbamylated, rivastigmine analogue, rational design, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight60604.48
Authors
Brazzolotto, X.,De la Mora, E.,Dighe, S.,Ross, B. (deposition date: 2017-10-30, release date: 2018-11-14)
Primary citation
Dighe, S.,De la Mora, E.,Chan, S.,Kantham, S.,McColl, G.,Veliyath, S.K.,Miles, J.A.,Nessar, Z.Y.,Mcgeary, R.,Silman, I.,Weik, I.,Parat, M.O.,Brazzolotto, X.,Ross, B.
Analogues of Rivastigmine and NAP for the CNS Delivery of Polyphenols with Putative Alzheimer Disease-Modifying Properties
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23911 0.4% 8.0% 5.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6eul
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Molmil generated image of 6eul
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Molmil generated image of 6eul
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