6ETI
Structure of inhibitor-bound ABCG2
Summary for 6ETI
Entry DOI | 10.2210/pdb6eti/pdb |
EMDB information | 3953 |
Descriptor | ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ... (5 entities in total) |
Functional Keywords | multidrug transporter, abcg2, mz29, inhibitor, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 241543.13 |
Authors | Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Altmann, K.H.,Locher, K.P. (deposition date: 2017-10-26, release date: 2018-04-11, Last modification date: 2020-07-29) |
Primary citation | Jackson, S.M.,Manolaridis, I.,Kowal, J.,Zechner, M.,Taylor, N.M.I.,Bause, M.,Bauer, S.,Bartholomaeus, R.,Bernhardt, G.,Koenig, B.,Buschauer, A.,Stahlberg, H.,Altmann, K.H.,Locher, K.P. Structural basis of small-molecule inhibition of human multidrug transporter ABCG2. Nat. Struct. Mol. Biol., 25:333-340, 2018 Cited by PubMed: 29610494DOI: 10.1038/s41594-018-0049-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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