6ET4

HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR

Summary for 6ET4

• Entry DOI: 10.2210/pdb6et4/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (10 entities in total)
• Functional Keywords: oxidoreductase, dhodh, cancer, p53 activation, pyrimidine synthesis
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
• Total number of polymer chains: 1
• Total formula weight: 41863.70

Authors

Hakansson, M.,Walse, B.,Gustavsson, A.-L.,Lain, S. (deposition date: 2017-10-25, release date: 2018-03-28, Last modification date: 2024-01-17)

• Primary citation: Ladds, M.J.G.W.,van Leeuwen, I.M.M.,Drummond, C.J.,Chu, S.,Healy, A.R.,Popova, G.,Pastor Fernandez, A.,Mollick, T.,Darekar, S.,Sedimbi, S.K.,Nekulova, M.,Sachweh, M.C.C.,Campbell, J.,Higgins, M.,Tuck, C.,Popa, M.,Safont, M.M.,Gelebart, P.,Fandalyuk, Z.,Thompson, A.M.,Svensson, R.,Gustavsson, A.L.,Johansson, L.,Farnegardh, K.,Yngve, U.,Saleh, A.,Haraldsson, M.,D'Hollander, A.C.A.,Franco, M.,Zhao, Y.,Hakansson, M.,Walse, B.,Larsson, K.,Peat, E.M.,Pelechano, V.,Lunec, J.,Vojtesek, B.,Carmena, M.,Earnshaw, W.C.,McCarthy, A.R.,Westwood, N.J.,Arsenian-Henriksson, M.,Lane, D.P.,Bhatia, R.,McCormack, E.,Lain, S.; A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.; Nat Commun, 9:1107-1107, 2018; PubMed: 29549331; DOI: 10.1038/s41467-018-03441-3

Experimental method

X-RAY DIFFRACTION (1.7 Å)