6ET4
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR
Summary for 6ET4
Entry DOI | 10.2210/pdb6et4/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (10 entities in total) |
Functional Keywords | oxidoreductase, dhodh, cancer, p53 activation, pyrimidine synthesis |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 41863.70 |
Authors | Hakansson, M.,Walse, B.,Gustavsson, A.-L.,Lain, S. (deposition date: 2017-10-25, release date: 2018-03-28, Last modification date: 2024-01-17) |
Primary citation | Ladds, M.J.G.W.,van Leeuwen, I.M.M.,Drummond, C.J.,Chu, S.,Healy, A.R.,Popova, G.,Pastor Fernandez, A.,Mollick, T.,Darekar, S.,Sedimbi, S.K.,Nekulova, M.,Sachweh, M.C.C.,Campbell, J.,Higgins, M.,Tuck, C.,Popa, M.,Safont, M.M.,Gelebart, P.,Fandalyuk, Z.,Thompson, A.M.,Svensson, R.,Gustavsson, A.L.,Johansson, L.,Farnegardh, K.,Yngve, U.,Saleh, A.,Haraldsson, M.,D'Hollander, A.C.A.,Franco, M.,Zhao, Y.,Hakansson, M.,Walse, B.,Larsson, K.,Peat, E.M.,Pelechano, V.,Lunec, J.,Vojtesek, B.,Carmena, M.,Earnshaw, W.C.,McCarthy, A.R.,Westwood, N.J.,Arsenian-Henriksson, M.,Lane, D.P.,Bhatia, R.,McCormack, E.,Lain, S. A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. Nat Commun, 9:1107-1107, 2018 Cited by PubMed: 29549331DOI: 10.1038/s41467-018-03441-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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